期刊
CHEMICAL SCIENCE
卷 12, 期 16, 页码 5910-5917出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc06907h
关键词
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资金
- Erasmus+ programme of the European Union
- Wellcome Trust [092506, 098335]
- EPSRC [EP/R51181X/1]
- MRC [MR/M008991/1]
- University of York
- Laidlaw Scholarship
- MRC [MR/M008991/1] Funding Source: UKRI
SABRE is a catalytic method that enhances the sensitivity of molecular detection by binding target substrates and para-hydrogen to a metal center. A simple co-ligand strategy overcomes the issue of weak binding with sterically large substrates, allowing for significant increase in signal size and efficiency of the catalysts.
Signal Amplification by Reversible Exchange (SABRE) is a catalytic method for improving the detection of molecules by magnetic resonance spectroscopy. It achieves this by simultaneously binding the target substrate (sub) and para-hydrogen to a metal centre. To date, sterically large substrates are relatively inaccessible to SABRE due to their weak binding leading to catalyst destabilisation. We overcome this problem here through a simple co-ligand strategy that allows the hyperpolarisation of a range of weakly binding and sterically encumbered N-heterocycles. The resulting H-1 NMR signal size is increased by up to 1400 times relative to their more usual Boltzmann controlled levels at 400 MHz. Hence, a significant reduction in scan time is achieved. The SABRE catalyst in these systems takes the form [IrX(H)(2)(NHC)(sulfoxide)(sub)] where X = Cl, Br or I. These complexes are shown to undergo very rapid ligand exchange and lower temperatures dramatically improve the efficiency of these SABRE catalysts.
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