期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 111, 期 -, 页码 6-24出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2016.12.034
关键词
Oxidized phospholipids; Biological activities; Analytics of oxidized phospholipids; Receptors of oxidized phospholipids
资金
- Stiftung fur Herzkreislaufkranheiten
- Swiss Heart Foundation
- Austrian Science Fund [P27682-B30, P22267-B21]
- Austrian Science Fund (FWF) [P22267, P27682] Funding Source: Austrian Science Fund (FWF)
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes. Rapidly accumulating evidence suggests that OxPLs are biomarkers of atherosclerosis and other pathologies. In addition, successful application of experimental drugs based on structural scaffold of OxPLs in animal models of inflammation was recently reported. This review briefly summarizes current knowledge on generation, methods of quantification and biological activities of OxPLs. Furthermore, receptor and cellular mechanisms of these effects are discussed. The goal of the review is to give a broad overview of this class of lipid mediators inducing pleiotropic biological effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据