期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 111, 期 -, 页码 309-315出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2016.10.497
关键词
4-hydroxynonenal; HNE-modified Proteins; Proteasome; Proteolysis; HNE metabolism
4-Hydroxynonenal (HNE) is one of the quantitatively most important products of lipid peroxidation. Due to its high toxicity it is quickly metabolized, however, a small share of HNE avoids enzymatic detoxification and reacts with biomolecules including proteins. The formation of HNE-protein-adducts is one of the accompanying processes in oxidative stress or redox disbalance. The modification of proteins might occur at several amino acids side chains, leading to a variety of products and having effects on the protein function and fate. This review summarizes current knowledge on the formation of HNE-modified proteins, their fate in mammalian cells and their potential role as a damaging agents during oxidative stress. Furthermore, the potential of HNE-modified proteins as biomarkers for several diseases are highlighted.
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