期刊
NEUROPSYCHOBIOLOGY
卷 80, 期 2, 页码 101-133出版社
KARGER
DOI: 10.1159/000513688
关键词
Neurotransmitters; Temperament; Psychopathology; Functional ensemble of temperament; Constructivism
This review discusses the benefits of using a functional constructivism approach in analyzing neurochemical biomarkers underlying temperament and psychopathology. It identifies eight systems and describes seven neurochemical ensembles, highlighting their roles in action construction and introducing formal symbols for future analysis. The possibility of constructivism-based unifying taxonomies of temperament and classifications of psychiatric disorders is demonstrated.
Background/Aims: Progress in the development of DSM/ICD taxonomies has revealed limitations of both label-based and dimensionality approaches. These approaches fail to address the contingent, nonlinear, context-dependent, and transient nature of those biomarkers linked to specific symptoms of psychopathology or to specific biobehavioural traits of healthy people (temperament). The present review aims to highlight the benefits of a functional constructivism approach in the analysis of neurochemical biomarkers underlying temperament and psychopathology. Method: A review was performed. Results: Eight systems are identified, and 7 neurochemical ensembles are described in detail. None of these systems is represented by a single neurotransmitter; all of them work in ensembles with each other. The functionality and relationships of these systems are presented here in association with their roles in action construction, with brief examples of psychopathology. The review introduces formal symbols for these systems to facilitate their more compact analysis in the future. Conclusion: This analysis demonstrates the possibility of constructivism-based unifying taxonomies of temperament (in the framework of the neurochemical model functional ensemble of temperament) and classifications of psychiatric disorders. Such taxonomies would present the biobehavioural individual differences as consistent behavioural patterns generated within a formally structured space of parameters related to the generation of behaviour.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据