期刊
FERMENTATION-BASEL
卷 7, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/fermentation7010017
关键词
lactic acid; lignocellulose-inhibitors; furans; Bacillus coagulans; xylose; thermophilic fermentation
The study identified a newly isolated Bacillus coagulans strain Azu-10 capable of efficiently producing lactic acid from xylose under optimal fermentation conditions, even in the presence of various lignocellulose-derived inhibitors. The strain exhibited high biomass and lactic acid production in the presence of furanic inhibitors, carboxylic acids, and phenolic compounds at different concentrations.
Effective lactic acid (LA) production from lignocellulosic biomass materials is challenged by several limitations related to pentose sugar utilization, inhibitory compounds, and/or fermentation conditions. In this study, a newly isolated Bacillus coagulans strain Azu-10 was obtained and showed homofermentative LA production from xylose with optimal fermentation conditions at 50 degrees C and pH 7.0. Growth of strain Azu-10 and LA-fermentation efficiency were evaluated in the presence of various lignocellulose-derived inhibitors (furans, carboxylic acids, and phenols) at different concentrations. Furanic lignocellulosic-derived inhibitors were completely detoxified. The strain has exhibited high biomass, complete xylose consumption, and high LA production in the presence of 1.0-4.0 g/L furfural and 1.0-5.0 g/L of hydroxymethyl furfural, separately. Moreover, strain Azu-10 exhibited high LA production in the presence of 5.0-15.0 g/L acetic acid, 5.0 g/L of formic acid, and up to 7.0 g/L of levulinic acid, separately. Besides, for phenolic compounds, p-coumaric acid was most toxic at 1.0 g/L, while syringaldehyde or p-hydroxybenzaldehyde, and vanillin at 1.0 g/L did not inhibit LA fermentation. The present study provides an interesting potential candidate for the thermophilic LA fermentation from lignocellulose-derived substrates at the industrial biorefinery level.
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