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Exosomes in Immune Regulation

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Dual targeting of PD-L1 and PD-L2 by PCED1B-AS1 via sponging hsa-miR-194-5p induces immunosuppression in hepatocellular carcinoma

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Summary: In HCC, PD-L1 and PD-L2 expression are highly correlated, while PCED1B-AS1 and hsa-miR-194-5p expression are up-regulated. PCED1B-AS1 interacts with hsa-miR-194-5p to inhibit PD-Ls expression, promoting immunosuppression in HCC cells. This study suggests a potential role of PCED1B-AS1 in regulating immune response and tumor behavior in HCC.

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