The effect of denosumab administration on bone metabolism for treatment of spinal metastasis

Background: We investigated changes in bone metabolism markers over time for evaluating the effect of denosumab following administration to patients with spinal metastasis. Methods: Subjects of this study were 28 patients treated at the Department of Orthopedic Surgery at Aichi Medical University. Results: At 6 months after denosumab intervention, measured TRAP-5b values were significantly lower compared to pre-intervention values in both the osteosclerotic lesion and osteolytic lesion groups. Conclusions: This change in bone metabolism marker values over time is one of the methods for evaluating the effect of treatment on bone tissue in cases of spinal metastasis.

Automated summary

Denosumab treatment resulted in significantly lower TRAP-5b values in both osteosclerotic and osteolytic lesion groups at 6 months, indicating its effectiveness in patients with spinal metastasis.