Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

T-cell acute lymphoblastic leukemia causes a disproportional amount of immature white blood cells in the patients' bone marrow. The significant undesired side effects associated with traditional chemotherapy treatment prompted us to study a more effective treatment strategy. We decorated polyisocyanopeptide scaffolds with the selective leukemia cell binding aptamer sgc8c and found that the polymers inhibit proliferation by G0/G1-phase arrest, serving as an opportunity for future therapeutic strategies.

Automated summary

T-cell acute lymphoblastic leukemia leads to an imbalance of immature white blood cells in the bone marrow, with significant undesired side effects associated with traditional chemotherapy treatment. Decorating polyisocyanopeptide scaffolds with the aptamer sgc8c has shown to inhibit proliferation through G0/G1-phase arrest, providing a potential avenue for future therapeutic strategies.