4.7 Article

Selective sensing of DNA and live/dead cells and histological imaging based on a perylene derivative

期刊

CHEMICAL COMMUNICATIONS
卷 57, 期 22, 页码 2776-2779

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00145k

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资金

  1. National Natural Science Foundation of China [21778013, 22077024, U20A200458]
  2. Natural Science Foundation of Hebei Province [B2020201092]
  3. Foundation of the Department of Science and Technology of Hebei Province [19241303D]
  4. Priority Strategy Project of Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education [ts2019002]

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A mannose-modified perylene monoimide derivative PMI-Man has been developed, which exhibits highly selective binding to double-stranded DNA molecules, potent live/dead cell imaging, and histological imaging via both confocal and light microscopies. This approach may be utilized to create a universal colorful staining method for human tissues suitable for both confocal and light microscopies.
A mannose-modified perylene monoimide derivative PMI-Man was developed, which shows highly selective binding to double-stranded DNA molecules, potent live/dead cell imaging, and histological imaging via both confocal and light microscopies. This approach can be used to develop a universal colorful staining method for human tissues for both confocal and light microscopies.

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