期刊
GREEN CHEMISTRY
卷 23, 期 5, 页码 -出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0gc04268d
关键词
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资金
- Research Foundation Flanders (FWO) (BioFact Excellence of Science project) [30902231]
- iBOF (Next-BIOREF)
- UAntwerp (BOF GOA)
- UAntwerp (CASCH Excellence Center)
- VLAIO/Catalisti (ARBOREF)
- BIO-HarT project
- Hercules and Francqui Foundation
The demethylation reaction of aromatic methyl ethers using mineral acid as a catalyst in high temperature pressurized water provides high yields of aromatic alcohols. Versatility of the method was demonstrated on various substrates, with up to 99% yield of aromatic alcohols in most cases. The method is scalable and can utilize biorenewable feedstock like wood and clove oil.
A green, efficient and cheap demethylation reaction of aromatic methyl ethers with mineral acid (HCl or H2SO4) as a catalyst in high temperature pressurized water provided the corresponding aromatic alcohols (phenols, catechols, pyrogallols) in high yield. 4-Propylguaiacol was chosen as a model, given the various applications of the 4-propylcatechol reaction product. This demethylation reaction could be easily scaled and biorenewable 4-propylguaiacol from wood and clove oil could also be applied as a feedstock. Greenness of the developed method versus state-of-the-art demethylation reactions was assessed by performing a quantitative and qualitative Green Metrics analysis. Versatility of the method was shown on a variety of aromatic methyl ethers containing (biorenewable) substrates, yielding up to 99% of the corresponding aromatic alcohols, in most cases just requiring simple extraction as work-up.
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