Mo@GAA-Fe3O4 MNPs: a highly efficient and environmentally friendly heterogeneous magnetic nanocatalyst for the synthesis of polyhydroquinoline derivatives

Polyhydroquinolines were efficiently obtained from a sequential four-component reaction between dimedone or 1,3-cyclohexandione, ethyl acetoacetate, or methyl acetoacetate as a beta-ketoester, aldehydes, and ammonium acetate, under the catalysis of Mo@GAA-Fe3O4 MNPs as a green, effective, recyclable, and environmentally friendly nanocatalyst. Due to its magnetic nature the prepared catalyst can be easily separated from the reaction mixture by an external magnet and reused several times without significant changes in catalytic activity and reaction efficiency. The catalyst was characterized using energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

Automated summary

Polyhydroquinolines can be efficiently synthesized using Mo@GAA-Fe3O4 MNPs as a catalysis, which shows good recyclability and catalytic efficiency, and can be easily separated from the reaction mixture by an external magnet. The catalyst was characterized using various analytical techniques to confirm its structure and properties.