Effect of Telemedicine Dietary Intervention on Endothelial Function in Patients with Type 2 Diabetes Mellitus on Mediterranean Diet

Background: Patients with type 2 diabetes mellitus (T2DM) have a high rate of cardiovascular disease (CVD). The Mediterranean diet is preferred for CVD prevention. Endothelial dysfunction is demonstrated early in T2DM. Objectives: To study the effects of dietary intervention of T2DM patients without known CVD on endothelial function and vascular inflammation. Methods: A prospective study enrolled 22 patients with T2DM. Patients were divided randomly into two groups: an intervention group with 12 patients (55 +/- 7 years old, 6 women) and a control group with 10 patients (59 +/- 10 years old, 5 women). Clinical evaluation included body mass index (BMI) and endothelial function measured by the flow mediated percent change (FMD%). Fasting blood was drawn on entry to the study and 3 months later, measuring C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), total cholesterol, triglycerides, and glycosylated hemoglobin (HbA1C%). The intervention was based on weekly telephone calls by a clinical dietitian for 3 months. Results: In the intervention group CRP and ICAM-1 were reduced (from 4.2 +/- 3.3 mg/dl to 0.4 +/- 0.5 mg/dl, P = 0.01 and from 258.6 +/- 98.3 ng/ml to 171.6 +/- 47.7 ng/ml, P = 0.004). Endothelial function (FMD%) was improved (from 0.5 +/- 8.0% to 9.5 +/- 11.5%, P = 0.014). No change was observed in BMI, HbA1C%, total cholesterol, and triglycerides levels in either group. Conclusions: Patients with T2DM on the Mediterranean diet who received a weekly telephone call for 3 months improved their endothelial function with reduction of markers of inflammation.

Automated summary

After 3 months of Mediterranean diet intervention and weekly telephone follow-up, T2DM patients showed improvements in endothelial function and reduction in inflammation markers. However, there were no changes in body mass index, HbA1C%, total cholesterol, and triglycerides levels.