期刊
MAGNETIC RESONANCE IN MEDICAL SCIENCES
卷 20, 期 1, 页码 1-17出版社
JPN SOC MAGNETIC RESONANCE MEDICINE
DOI: 10.2463/mrms.rev.2019-0094
关键词
C-13 metabolic MRI; dynamic nuclear polarization; hyperpolarization; molecular imaging; parahydrogen-induced polarization
Since the first report on hyperpolarized [1-C-13]pyruvate magnetic resonance imaging in prostate cancer patients, rapid clinical dissemination of the technique has occurred. The use of hyperpolarized C-13 probes has expanded to study pathophysiological processes beyond the Warburg effect, with promising preclinical results leading to pending clinical translation. Recent technological advances have facilitated the realization of high-sensitivity, multi-functional molecular MRI using simultaneous injection of co-polarized agents.
Since the first pioneering report of hyperpolarized [1-C-13]pyruvate magnetic resonance imaging (MRI) of the Warburg effect in prostate cancer patients, clinical dissemination of the technique has been rapid; close to 10 sites worldwide now possess a polarizer fit for the clinic, and more than 30 clinical trials, predominantly for oncological applications, are already registered on the US and European clinical trials databases. Hyperpolarized C-13 probes to study pathophysiological processes beyond the Warburg effect, including tricarboxylic acid cycle metabolism, intra-cellular pH and cellular necrosis have also been demonstrated in the preclinical arena and are pending clinical translation, and the simultaneous injection of multiple co-polarized agents is opening the door to high-sensitivity, multi-functional molecular MRI with a single dose. Here, we review the biomedical applications to date of the two polarization methods that have been used for in vivo hyperpolarized C-13 molecular MRI; namely, dissolution dynamic nuclear polarization and parahydrogen-induced polarization. The basic concept of hyperpolarization and the fundamental theory underpinning these two key C-13 hyperpolarization methods, along with recent technological advances that have facilitated biomedical realization, are also covered.
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