期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 23, 页码 2854-2866出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc07750j
关键词
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资金
- Basic Science Research Program [2018R1D1A1B07050867, 2018R1A2B3006080, 2020R1A6A3A01100335]
- Korean Research Fellowship of the National Research Foundation, Republic of Korea [2016H1D3A1909300]
- National Research Foundation of Korea [2016H1D3A1909300] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Sonodynamic therapy (SDT) has emerged as a promising alternative to conventional cancer therapies due to its safety and cost-effectiveness. However, the insufficient reactive oxygen species (ROS) production of current sonosensitizers has hindered its clinical application. Recent nanomaterial-based SDT strategies aim to improve sonosensitizer efficiency and enhance oxidative stress for potential anti-tumor immunity.
With interest in non-invasiveness and safety in cancer treatment, sonodynamic therapy (SDT) has emerged as a promising alternative to conventional cancer therapies. SDT offers safety and cost-effectiveness and exhibits a broad application range that is superior to photodynamic therapy. However, the insufficient reactive oxygen species (ROS) production of current sonosensitizers has hindered its clinical application to date. In this review, the ROS-generation mechanism in SDT and the limitations of current sonosensitizers are briefly reviewed. Also, highlighted are recent nanomaterial-based SDT strategies to improve the efficiency of sonosensitizers, amplify oxidative stress, and elicit antitumor immunity.
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