期刊
NANOSCALE
卷 13, 期 13, 页码 6394-6399出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr08887k
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资金
- National Natural Science Foundation of China [52022043]
- Tsinghua UniversityPeking Union Medical College Hospital Initiative Scientific Research Program [20191080593]
- Precision Medicine Foundation, Tsinghua University, China [10001020107]
- China Postdoctoral Science Foundation [2019M660620]
- Research Fund of State Key Laboratory of Tribology, Tsinghua University, China [SKLT2020C11]
The visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles and beta-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) can effectively induce drug release after passing through the dermal tissue and enhance lubrication, which is beneficial for the treatment of osteoarthritis.
Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and beta-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.
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