期刊
ANNALS OF THE RHEUMATIC DISEASES
卷 80, 期 4, 页码 413-422出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/annrheumdis-2020-218089
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资金
- Key Programme of Natural Science Foundation of China [81930067]
- Project of Nature Science Foundation of China [31870962]
- Medical Science and Technology Youth Cultivation Project of PLA [20QNPY022]
- Innovation Funding of TMMU [2018XYY05]
- Medical Innovation Capability Upgrading Plan of Southwest Hospital [SWH2018LJ-03]
- Medical Innovation of Graduate Students in Chongqing [CYS19360]
This article discusses the changes in subchondral bone during OA progression and potential strategies for treating OA, including restoring abnormal remodeling and blocking blood vessels, highlighting the relationship between the subchondral bone microenvironment and OA pain.
Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been considered as primarily a disease of the articular cartilage, the participation of subchondral bone in the pathogenesis of OA has attracted increasing attention. This review summarises the microstructural and histopathological changes in subchondral bone during OA progression that are due, at the cellular level, to changes in the interactions among osteocytes, osteoblasts, osteoclasts (OCs), endothelial cells and sensory neurons. Therefore, we focus on how pathological cellular interactions in the subchondral bone microenvironment promote subchondral bone destruction at different stages of OA progression. In addition, the limited amount of research on the communication between OCs in subchondral bone and chondrocytes (CCs) in articular cartilage during OA progression is reviewed. We propose the concept of 'OC-CC crosstalk' and describe the various pathways by which the two cell types might interact. Based on the 'OC-CC crosstalk', we elaborate potential therapeutic strategies for the treatment of OA, including restoring abnormal subchondral bone remodelling and blocking the bridge-subchondral type H vessels. Finally, the review summarises the current understanding of how the subchondral bone microenvironment is related to OA pain and describes potential interventions to reduce OA pain by targeting the subchondral bone microenvironment.
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