期刊
NANOSCALE
卷 13, 期 8, 页码 4634-4643出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr08878a
关键词
-
类别
资金
- National Natural Science Foundation of China [31771103]
- CAS Emergency Project of ASF Research [KJZD-SW-L06-02]
- Wuhan Science and Technology Bureau [2018060401011327]
- Scientific Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20190057]
Dps, a natural protein nanocage, has been developed for antioxidant treatment by inhibiting the generation of ROS. With its ferroxidase activity, Dps not only protects cells from oxidative stress but also alleviates inflammation induced by ROS. This unique material shows great potential in various applications such as antiaging, anti-inflammation, and cosmetics.
Elevated levels of reactive oxygen species (ROS) are implicated in the onset and progression of many diseases, e.g., virus infection, ischemic stroke and neurodegenerative diseases. ROS-scavenging nanomaterials have attracted particular interest. Here, we report the development of a natural protein nanocage named Dps for in vitro and in vivo antioxidant treatment by inhibiting the Fenton reaction, a critical step in ROS generation and interconversion. Systematic surface engineering enabled cell penetration, good colloidal stability, and facile purification of Dps. With its intrinsic ferroxidase activity consuming both H2O2 and Fe2+, Dps not only protects human cells from oxidative stress but also effectively alleviates ROS-induced inflammation in a mouse dermatitis model. The protection is triggered by elevated H2O2 and thereby, in principle, avoids ROS imbalances. Thus, Dps has potential as a new bionano platform for different purposes, such as antiaging, anti-inflammation and cosmetics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据