Association Between the Anti-Aging Gene Klotho and Selected Rheumatologic Autoimmune Diseases

Klotho long recognized for its role in anti-aging, is potentially implicated in the pathogenesis of rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Aging of the immune system coincides with the inability of the body to recognize self-antigens, which often leads to autoimmune responses. The role of Klotho in these autoimmune diseases should be of high interest; however, few articles have been published exploring the role of Klotho in the pathogenesis, organ involvement, or clinical manifestation of rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Herein, we discuss information gathered from peer-reviewed publications to describe the emerging role of Kl in these select rheumatologic autoimmune diseases.

Automated summary

Klotho, traditionally known for its anti-aging properties, is now being explored for its potential role in the pathogenesis of autoimmune diseases such as rheumatoid arthritis, calling for further research and study.