期刊
AGING-US
卷 13, 期 5, 页码 6999-7019出版社
IMPACT JOURNALS LLC
关键词
esophageal cancer; prognostic markers; copy number variation; methylation; multi-omics associated analysis
资金
- National Natural Science Foundation of China [81802327]
- China postdoctoral science funding [2019M660009]
This study identified high consistency between DNA copy number variations and abnormal methylations in esophageal cancer, and determined three subtypes with different molecular traits, prognostic characteristics, and tumor immune microenvironment features. The study also identified 4 prognostic genes differentially expressed in the three subtypes, which could be used as representative biomarkers for precision medication in esophageal cancer.
Esophageal cancer (EC) involves many genomic, epigenetic and transcriptomic disorders, which play key roles in the heterogeneous progression of cancer. However, the study of EC with multi-omics has not been conducted. This study identified a high consistency between DNA copy number variations and abnormal methylations in EC by analyzing genomics, epigenetics and transcriptomics data and investigating mutual correlations of DNA copy number variation, methylation and gene expressions, and stratified copy number variation genes (CNV-Gs) and methylation genes (MET-Gs). The methylation, CNVs and expression profiles of CNV-Gs and MET-Gs were analyzed by consistent clustering using iCluster integration, here, we determined three subtypes (iC1, iC2, iC3) with different molecular traits, prognostic characteristics and tumor immune microenvironment features. We also identified 4 prognostic genes (CLDN3, FAM221A, GDF15 and YBX2) differentially expressed in the three subtypes, and could therefore be used as representative biomarkers for the three subtypes of EC. In conclusion, by performing comprehensive analysis on genomic, epigenetic and transcriptomic regulations, the current study provided new insights into the multilayer molecular and pathological traits of EC, and contributed to the precision medication for EC patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据