期刊
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
卷 48, 期 2, 页码 157-171出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/cjn.2020.166
关键词
Pediatric; MRI; Neuroimaging; Cerebral palsy; Resting state; Stroke
资金
- Canadian Institute of Health Research (CIHR) Vanier Canadian Graduate Scholarship
- CIHR
Perinatal stroke can lead to lifelong neurological disabilities, and MRI has played a crucial role in studying developmental neuroplasticity following injury. Techniques such as structural imaging, diffusion tensor imaging, functional MRI, and spectroscopy can be used to investigate neuroplasticity models in children with perinatal stroke.
Perinatal stroke occurs around the time of birth and leads to lifelong neurological disabilities including hemiparetic cerebral palsy. Magnetic resonance imaging (MRI) has revolutionized our understanding of developmental neuroplasticity following early injury, quantifying volumetric, structural, functional, and metabolic compensatory changes after perinatal stroke. Such techniques can also be used to investigate how the brain responds to treatment (interventional neuroplasticity). Here, we review the current state of knowledge of how established and emerging neuroimaging modalities are informing neuroplasticity models in children with perinatal stroke. Specifically, we review structural imaging characterizing lesion characteristics and volumetrics, diffusion tensor imaging investigating white matter tracts and networks, task-based functional MRI for localizing function, resting state functional imaging for characterizing functional connectomes, and spectroscopy examining neurometabolic changes. Key challenges and exciting avenues for future investigations are also considered.
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