期刊
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
卷 4, 期 2, 页码 563-567出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsptsci.0c00192
关键词
psychedelic; psychoplastogen; neural plasticity; hallucinogen; neuropsychiatric disorder; post-traumatic stress disorder; substance use disorder; antidepressant; depression; 5-HT2A receptor
资金
- National Institutes of Health (NIH) [R01GM128997]
Psychedelics have shown promise for treating neuropsychiatric disorders due to their ability to promote neural plasticity and produce rapid and sustained therapeutic effects, but evidence suggests that the subjective effects induced by these drugs may not be necessary for long-lasting changes in mood and behavior. Understanding the role of subjective effects in the therapeutic mechanisms of psychedelics will have important implications for basic neuroscience and patient access to future medicines developed from psychedelic research.
Psychedelics represent one of the most promising classes of experimental medicines for the treatment of neuropsychiatric disorders due to their ability to promote neural plasticity and produce both rapid and sustained therapeutic effects following a single administration. Conventional wisdom holds that peak mystical experiences induced by psychedelics are a critical component of their therapeutic mechanisms of action, though evidence supporting that claim is largely correlational. Here, I present data suggesting that the subjective effects induced by psychedelics may not be necessary to produce long-lasting changes in mood and behavior. Understanding the role of subjective effects in the therapeutic mechanisms of psychedelics will have important implications for both basic neuroscience and for increasing patient access to the next generation of medicines developed as a result of psychedelic research.
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