期刊
FEMS MICROBIOLOGY REVIEWS
卷 45, 期 5, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fuab020
关键词
transcriptional factors; gene regulation; biotechnology; regulatory networks; AraC/XylS
类别
资金
- Consejo Nacional de Ciencia y Tecnologia [CONACYT A1-S-25438]
- Secretaria de Investigaci 'on y Posgrado (IPN) [SIP-20200728]
- Direcci 'on General de Asuntos del Personal Academico-Universidad Nacional Autonoma de Mexico [IN-209620]
- CYTED [P918PTE0261]
- CONACYT [935269]
- BEIFI-IPN scholarship
- COFAA-IPN
- EDI-IPN
- SNI-CONACyT
Transcriptional factors are vital in gene regulation across organisms, especially in Bacteria. The AraC/XylS family of transcriptional regulators is diverse and can be clustered based on functional classification. Experimental evidence and bioinformatics tools are used to update information and propose grouping for these proteins, aiming to stimulate future research in the field.
Transcriptional factors play an important role in gene regulation in all organisms, especially in Bacteria. Here special emphasis is placed in the AraC/XylS family of transcriptional regulators. This is one of the most abundant as many predicted members have been identified and more members are added because more bacterial genomes are sequenced. Given the way more experimental evidence has mounded in the past decades, we decided to update the information about this captivating family of proteins. Using bioinformatics tools on all the data available for experimentally characterized members of this family, we found that many members that display a similar functional classification can be clustered together and in some cases they have a similar regulatory scheme. A proposal for grouping these proteins is also discussed. Additionally, an analysis of surveyed proteins in bacterial genomes is presented. Altogether, the current review presents a panoramic view into this family and we hope it helps to stimulate future research in the field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据