期刊
NATURE METABOLISM
卷 3, 期 4, 页码 523-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s42255-021-00383-x
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资金
- Abbott
- Zoe Global Ltd
- Massachusetts General Hospital
- Translational and Clinical Research Center
- Wellcome Trust [212904/Z/18/Z]
- Medical Research Council (MRC)/British Heart Foundation Ancestry and Biological Informative Markers for Stratification of Hypertension [MR/M016560/1]
- European Research Council [CoG-2015_681742_NASCENT]
- Swedish Research Council
- Novo Nordisk Foundation
- Swedish Foundation for Strategic Research (IRC award)
- National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre
- MRC
- European Union
- Chronic Disease Research Foundation
- NIHR-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London
- NIHR
- Wellcome Trust [212904/Z/18/Z] Funding Source: Wellcome Trust
Research suggests that postprandial glucose dips at 2-3 hours after a meal are a better predictor of hunger and subsequent energy intake compared to peak glucose levels at 0-2 hours. Understanding the relationship between postprandial glucose, appetite, and energy intake can provide valuable insights into weight loss interventions.
Understanding how to modulate appetite in humans is key to developing successful weight loss interventions. Here, we showed that postprandial glucose dips 2-3 h after a meal are a better predictor of postprandial self-reported hunger and subsequent energy intake than peak glucose at 0-2 h and glucose incremental area under the blood glucose curve at 0-2 h. We explore the links among postprandial glucose, appetite and subsequent energy intake in 1,070 participants from a UK exploratory and US validation cohort, who consumed 8,624 standardized meals followed by 71,715 ad libitum meals, using continuous glucose monitors to record postprandial glycaemia. For participants eating each of the standardized meals, the average postprandial glucose dip at 2-3 h relative to baseline level predicted an increase in hunger at 2-3 h (r = 0.16, P < 0.001), shorter time until next meal (r = -0.14, P < 0.001), greater energy intake at 3-4 h (r = 0.19, P < 0.001) and greater energy intake at 24 h (r = 0.27, P < 0.001). Results were directionally consistent in the US validation cohort. These data provide a quantitative assessment of the relevance of postprandial glycaemia in appetite and energy intake modulation. Wyatt et al. explore glycaemic responses after a standardized meal and find that postprandial glycaemic dip is a predictor of hunger and subsequent energy intake.
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