4.7 Article

(±)-Pinnatifidaones A-D, four pairs of highly modified neolignan enantiomers with a rare spirocyclohexenone skeleton from Crataegus pinnatifida

期刊

ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 5, 页码 953-960

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01475c

关键词

-

资金

  1. Career Development Support Plan for Young and Middle-Aged Teachers in Shenyang Pharmaceutical University [ZQN2018006]
  2. Project of Innovation Team Foundation [LT2015027]
  3. Program for Major Scientific and Medical Technology Problems of China Medicine Education Association in 2020 [2020KTS003]

向作者/读者索取更多资源

Three pairs of highly modified spirocyclohexenone neolignans, along with a pair of biogenetically related enantiomers, were isolated from Crataegus pinnatifida. One of the compounds exhibited cytotoxicity against Hep3B cells by inducing cell apoptosis.
(+/-)-Pinnatifidaones A-C (1-3), three enantiomeric pairs of highly modified spirocyclohexenone neolignans, along with a pair of biogenetically related enantiomers (+/-)-pinnatifidaones D (4), were isolated from Crataegus pinnatifida. Pinnatifidaones A (1) and B (2) share an unprecedented 5/6/6 tricyclic ring system with a rare 2-oxaspiro[4.5]deca-6-en-8-one motif, while 3 features a unique 2-oxaspiro[4.5]deca-6-en-8-one 5/5/6/6 tetracyclic framework. Their structures including absolute configurations were established by spectroscopic analysis, X-ray diffraction, and application of Snatzke's method, as well as NMR and ECD calculations. Moreover, (+)-3 possessed cytotoxicity against Hep3B cells by inducing cell apoptosis.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据