期刊
AGING CLINICAL AND EXPERIMENTAL RESEARCH
卷 33, 期 4, 页码 1133-1144出版社
SPRINGER
DOI: 10.1007/s40520-021-01808-z
关键词
Cardiovascular magnetic resonance; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
资金
- British Heart Foundation Clinical Research Training Fellowship [FS/17/81/33318]
- Barts Biomedical Research Centre - National Institute for Health Research (NIHR)
- European Union [825903]
- SmartHeart EPSRC programme grant [EP/P001009/1]
- Oxford NIHR Biomedical Research Centre
- Oxford British Heart Foundation Centre of Research Excellence
- UK Medical Research Council (MRC) [405050259, U105960371]
- NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton
- British Heart Foundation [PG/14/89/31194]
- British Heart Foundation Oxford CRE Transition Fellowship
- NIHR Oxford BRC
- Medical College of Saint Bartholomew's Hospital Trust
- London School of Medicine and Dentistry
- London Medical Imaging and Artificial Intelligence Centre for Value Based Healthcare (AI4VBH) from the Data to Early Diagnosis and Precision Medicine strand of the government's Industrial Strategy Challenge Fund
- EPSRC [EP/P001009/1] Funding Source: UKRI
The study found that individuals with adverse baseline cardiovascular magnetic resonance phenotypes had a higher likelihood of testing positive for COVID-19, independent of traditional cardiovascular risk factors. Therefore, observational reports of cardiovascular involvement after COVID-19 may partly reflect pre-existing cardiac conditions.
Background Coronavirus disease 2019 (COVID-19) disproportionately affects older people. Observational studies suggest indolent cardiovascular involvement after recovery from acute COVID-19. However, these findings may reflect pre-existing cardiac phenotypes. Aims We tested the association of baseline cardiovascular magnetic resonance (CMR) phenotypes with incident COVID-19. Methods We studied UK Biobank participants with CMR imaging and COVID-19 testing. We considered left and right ventricular (LV, RV) volumes, ejection fractions, and stroke volumes, LV mass, LV strain, native T1, aortic distensibility, and arterial stiffness index. COVID-19 test results were obtained from Public Health England. Co-morbidities were ascertained from self-report and hospital episode statistics (HES). Critical care admission and death were from HES and death register records. We investigated the association of each cardiovascular measure with COVID-19 test result in multivariable logistic regression models adjusting for age, sex, ethnicity, deprivation, body mass index, smoking, diabetes, hypertension, high cholesterol, and prior myocardial infarction. Results We studied 310 participants (n = 70 positive). Median age was 63.8 [57.5, 72.1] years; 51.0% (n = 158) were male. 78.7% (n = 244) were tested in hospital, 3.5% (n = 11) required critical care admission, and 6.1% (n = 19) died. In fully adjusted models, smaller LV/RV end-diastolic volumes, smaller LV stroke volume, and poorer global longitudinal strain were associated with significantly higher odds of COVID-19 positivity. Discussion We demonstrate association of pre-existing adverse CMR phenotypes with greater odds of COVID-19 positivity independent of classical cardiovascular risk factors. Conclusions Observational reports of cardiovascular involvement after COVID-19 may, at least partly, reflect pre-existing cardiac status rather than COVID-19 induced alterations.
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