4.4 Article

Differential Effects of Wedelia chinensis on Human Glioblastoma Multiforme Cells

期刊

INTEGRATIVE CANCER THERAPIES
卷 20, 期 -, 页码 -

出版社

SAGE PUBLICATIONS INC
DOI: 10.1177/15347354211000119

关键词

glioblastoma multiforme; traditional Chinese medicine; Wedelia chinensis extract; apoptosis; autophagy

资金

  1. Kaohsiung Armed Force General Hospital, Kaohsiung, Taiwan [106-04]
  2. Ministry of Science and Technology [MOST-1072314-B040-004, MOST-108-2320-B-040-024-MY3]

向作者/读者索取更多资源

The extract of Wedelia chinensis showed significant inhibitory effects on the proliferation and invasion of glioblastoma cells, with differential effects observed on different cell lines. Additionally, the combination of luteolin and apigenin also significantly reduced cell survival and invasive capabilities in glioblastoma cells. Further research is needed to consider these as standard treatments for GBM.
Introduction: Glioblastoma multiforme (GBM) is the most aggressive glioma, and its diffuse nature makes resection of it difficult. Moreover, even with the administration of postoperative radiotherapy and chemotherapy, prolonged remission is often not achieved. Hence, innovative or alternative treatments for GBM are urgently required. Traditional Chinese herbs and their functional components have long been used in the treatment of various cancers, including GBM. The current study investigated the antitumor activity of Wedelia chinensis and its major functional components, luteolin and apigenin, on GBM. Materials and Methods: MTT assay, Transwell migration assay, and flow cytometry analysis were adopted to assess the cell viability, invasive capability, and cell cycle. Immunofluorescence staining and Western blotting were used to detect the expressions of apoptotic and autophagy-related signaling molecules. Results: The W. chinensis extract (WCE) significantly inhibited the proliferation and invasive ability of both GBM8401 and U-87MG cells in a dose-dependent manner. Moreover, differential effects of WCE on GBM8401 and U-87MG cells were observed: WCE induced apoptosis in GBM8401 cells and autophagy in U-87MG cells. Notably, WCE had significant effects in reducing the cell survival and invasive capability of both GBM8401 and U-87MG cells than the combination of luteolin and apigenin. Conclusions: Taken together, these findings indicate the potential of using WCE and the combination of luteolin and apigenin for GBM treatment. However, further investigations are warranted before considering recommending the clinical use of WCE or the combination of luteolin and apigenin as the standard for GBM treatment.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据