期刊
NON-CODING RNA
卷 7, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ncrna7010003
关键词
long non-coding RNA; mRNA stability; RNA binding protein; microRNA; gene expression
资金
- European Foundation for the Study of Diabetes (EFSD)-EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research
- Spanish Ministry of Science, Innovation and Universities [PID2019-104475GA-I00, SAF2017-91873-EXP, PGC2018-097573-A-I00]
- UPV/EHU (Universidad del Pais Vasco/Euskal Herriko Unibertsitatea)
- Education Department of Basque Government
mRNA stability is crucial for gene expression and translation, and is determined by a balance between production and decay in the cell. Long non-coding RNAs (lncRNAs) play a role in regulating gene expression by modulating mRNA stability through interactions with RNA binding proteins and microRNAs, as well as by modulating epitranscriptomic marks that impact mRNA stability.
mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological processes and to maintain an appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of gene expression through different molecular mechanisms, including mRNA stabilization. In this review we provide an overview on the molecular mechanisms by which lncRNAs modulate mRNA stability and decay. We focus on how lncRNAs interact with RNA binding proteins and microRNAs to avoid mRNA degradation, and also on how lncRNAs modulate epitranscriptomic marks that directly impact on mRNA stability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据