pH Assists For Selective Determination Of Acyclovir By The Emission Enhancement Of Tb3+ Chemosensor In Tablet And Serum Samples

A new selective method for the determination of acyclovir in pharmaceutical tablet and serum samples was developed. The method depends on the luminescence enhancement of Tb3+ chemosensor with different concentrations of acyclovir at pH 10. Acyclovir can form a complex with Tb3+ ion of 3:1 molar ratio in DMSO, respectively. The luminescence intensity of Tb3+-acyclovir complex increases as the concentration of the drug increases at lambda(ex)=320 nm, pH 10 in DMSO. The linear range for determination of the selected drug in DMSO 1.0 x 10(-9) -1 x 10(-5) mol L-1 the detection limits were 0.24 x 10(-9) mol L-1.

Automated summary

A new selective method for determining acyclovir in pharmaceutical tablet and serum samples was developed based on the luminescence enhancement of a Tb3+ chemosensor. Acyclovir can form a complex with Tb3+ ion in DMSO, and the luminescence intensity of the complex increases with increasing drug concentration. The linear range for determination of acyclovir in DMSO was found to be 1.0 x 10(-9) - 1 x 10(-5) mol L-1 with a detection limit of 0.24 x 10(-9) mol L-1.