期刊
RSC CHEMICAL BIOLOGY
卷 2, 期 3, 页码 743-758出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cb00225a
关键词
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资金
- National Natural Science Foundation of China [22022404, 22074050, 21708012, 81600459, 51402099]
- Wuhan scientific and technological projects [2019020701011441]
- NSF of Hubei Province [2017CFB151]
- Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization [2018B030322009]
- Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control [KHK1909]
- State Key Laboratory of Fine Chemicals, Dalian University of Technology [KF 1907]
Photoacoustic imaging (PAI) is attracting attention for its integration of high spatial resolution and deep tissue penetration. Near-infrared (NIR) PAI has rapidly developed in biomedical field, showing significant advantages over visible light region.
Photoacoustic imaging (PAI), which integrates the higher spatial resolution of optical imaging and the deeper penetration depth of ultrasound imaging, has attracted great attention. Various photoacoustic probes including inorganic and organic agents have been well fabricated in last decades. Among them, small-molecule based agents are most promising candidates for preclinical/clinical applications due to their favorite in vivo features and facile functionalization. In recent years, PAI, in the near-infrared region (NIR, 700-1700 nm) has developed rapidly and has made remarkable achievements in the biomedical field. Compared with the visible light region (400-700 nm), it can significantly reduce light scattering and meanwhile provide deeper tissue penetration. In this review, we discuss the recent developments of near-infrared photoacoustic probes based on small molecule dyes, which focus on their always on and activatable form in biomedicine. Further, we also suggest current challenges and perspectives.
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