期刊
BIOENGINEERED
卷 12, 期 1, 页码 1150-1160出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2021.1909951
关键词
Gastric cancer; miR-1269b; METTL3; proliferation; metastasis
The study demonstrated that miR-1269b inhibits the progression of gastric cancer by targeting METTL3, with low expression associated with larger tumor size and lymph node metastasis.
The dysregulation of microRNAs (miRNAs) expression is relevant to the progression of many tumors. As reported, the abnormal expression of miR-1269b is pivotal in certain cancers' progression. This work was designed to study the role and hidden mechanism of miR-1269b in gastric cancer (GC) progression. In this work, we proved that miR-1269b was lowly expressed in GC tissues and cell lines, which was associated with larger tumor size and lymph node metastasis. MiR-1269b overexpression repressed the multiplication, migration and invasion of GC cells while miR-1269b inhibition had the opposite effects. Methyltransferase-like 3 (METTL3) was identified as the direct target of miR-1269b in GC cells, and its overexpression reversed the inhibitory effect of transfection of miR-1269b mimics on GC cell viability, migration and invasion. On all accounts, these data indicated that miR-1269b inhibits GC progression via targeting METTL3.
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