期刊
ACS APPLIED BIO MATERIALS
卷 4, 期 3, 页码 2217-2230出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01561
关键词
ebselen-agents; fluorescent sensor; derivatization reagents; activity-based protein profiling (ABPP); chemical proteomics
资金
- National Natural Science Foundation of China [21305076, ZR2019MB005]
- Shandong Provincial Natural Science Foundation
The article provides a systematic summary of the application of ebselen agents in biochemistry, including synthetic strategies, functional applicability, and current challenges faced in biological research.
Phenyl-1,2-benzoselenazol-3(2H)-one (ebselen) is a classical mimic of glutathione peroxidase (GPx). Thioredoxin interaction endows ebselen attractive biological functions, such as antioxidation and anti-infection, as well as versatile therapeutic usage. Accordingly, application of ebselen analogues in biosensing, chemical labeling, imaging analysis, disease pathology, drug development, clinical treatment, etc. have been widely developed, in which mercaptans, reactive oxygen species, reactive sulfur species, peptides, and proteins were involved. Herein, focusing on the application of ebselen-agents in biochemistry, we have made a systematic summary and comprehensive review. First, we summarized both the classical and the innovative methods for preparing ebselen-agents to present the synthetic strategies. Then we discussed the full functional applicability of ebselen analogues in three fields of biochemical analysis including the fluorescence sensing and bioimaging, derivatization for high throughput fluorescence analysis, and the labeling gents for proteomics. Finally, we discussed the current challenges and perspectives for ebselen-agents as analytical tools in biological research. By presenting the multifunctional applicability of ebselen, we hope this review could appeal researchers to design the ebselen-related biomaterials for biochemical analysis.
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