4.0 Article

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) versus adult T-cell leukemia/lymphoma (ATLL)

期刊

BMC RESEARCH NOTES
卷 14, 期 1, 页码 -

出版社

SPRINGERNATURE
DOI: 10.1186/s13104-021-05521-y

关键词

Human T-lymphotropic virus type 1; HTLV-1 associated myelopathy; tropical spastic paraparesis; Adult T-cell leukemia; lymphoma; Pathogenesis; Systems virology

资金

  1. Alborz University of Medical Sciences (ABZUMS)

向作者/读者索取更多资源

This study identified important signaling pathways related to positive regulation of transcription and histone modification in the interaction network of HAM/TSP and ATLL. Several hub genes were found to be commonly upregulated or downregulated in both diseases according to ontology-based enrichment analysis. The results provide insights into the interactions between HTLV-1 and host cells in HAM/TSP and ATLL.
ObjectivesHuman T cell leukemia virus-1 (HTLV-1) infection may lead to one or both diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T cell leukemia lymphoma (ATLL). The complete interactions of the virus with host cells in both diseases is yet to be determined. This study aims to construct an interaction network for distinct signaling pathways in these diseases based on finding differentially expressed genes (DEGs) between HAM/TSP and ATLL.ResultsWe identified 57 hub genes with higher criteria scores in the primary protein-protein interaction network (PPIN). The ontology-based enrichment analysis revealed following important terms: positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle and positive regulation of transcription from RNA polymerase II promoter by histone modification. The upregulated genes TNF, PIK3R1, HGF, NFKBIA, CTNNB1, ESR1, SMAD2, PPARG and downregulated genes VEGFA, TLR2, STAT3, TLR4, TP53, CHUK, SERPINE1, CREB1 and BRCA1 were commonly observed in all the three enriched terms in HAM/TSP vs. ATLL. The constructed interaction network was then visualized inside a mirrored map of signaling pathways for ATLL and HAM/TSP, so that the functions of hub genes were specified in both diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.0
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据