期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 21, 页码 2649-2652出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00160d
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资金
- National Natural Science Foundation [21971252, 21991122]
- Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS) [QYZDJSSWSLH049]
- Youth Innovation Promotion Association CAS [2019256]
The study presents a Cu-catalyzed reaction that does not require toxic cyanation reagents, using BrCF2CO2Et and NH4HCO3 under photocatalytic conditions to achieve the cyanodifluoromethylation of alkenes. The Cu-complex serves as both a photocatalyst and a coupling catalyst for the formation of a C-CN bond.
Although cyanofluoroalkylation has received increasing attention, a toxic cyanation reagent is usually required. Herein, a Cu-catalyzed difluorocarbene-based cyanodifluoromethylation of alkenes with BrCF2CO2Et/NH4HCO3 under photocatalytic conditions is described. BrCF2CO2Et and NH4HCO3 serve as a carbon source and a nitrogen source of the nitrile group, respectively, avoiding the use of a stoichiometric toxic cyanation reagent. The Cu-complex plays a dual role. It is not only a photocatalyst, but also a coupling catalyst for the formation of a C-CN bond.
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