期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 21, 页码 2681-2684出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc08226k
关键词
-
资金
- Ministry of Culture and Science within the framework of the NRW Strategieprojekt BioSC [313/323-400-00213]
The semi-rational redesign of substrate binding pocket and access tunnels in PigC significantly enhanced catalytic efficiency in synthesizing anti-cancer agents, while providing a better understanding of residues V333 and T334 related to substrate binding and translocation through PigC access tunnels.
Semi-rational redesign of the substrate binding pocket and access tunnels of prodigiosin ligase PigC enhanced the catalytic efficiency in the synthesis of pyrrolic anti-cancer agents more than 45 times. A molecular understanding was gained on residues V333 and T334 relevant to substrate binding and translocation of small pyrroles through PigC access tunnels.
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