期刊
AGEING RESEARCH REVIEWS
卷 24, 期 -, 页码 206-217出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2015.08.004
关键词
Autophagy; Bone; Osteoporosis
资金
- Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA)
- University of Nice Sophia Antipolis (UNS)
- Societe Francaise de Rhumatologie (SFR)
- Groupe de Recherche et d'Information sur les Osteoporoses (GRID)
- Associations Les Anges de Verre
- France Cancer [06]
Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight the autophagy role in the different bone cell types, i.e., osteoblasts, osteoclasts and osteocytes. We also discuss the effects of autophagy modulators in bone physiology and of bone anabolic compounds in autophagy. Finally, we analyzed studies regarding bone cell autophagy-deficient mouse models to obtain a more general view on how autophagy modulates bone physiology and pathophysiology, particularly during aging. (C) 2015 Elsevier B.V. All rights reserved.
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