期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 49, 期 3, 页码 577-608出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X21500269
关键词
Oligosaccharides; Chemical Diversity; Biological Activities; Traditional Chinese Herbal Medicines; Review
资金
- National Natural Science Foundation of China [82074007]
- Guangdong Province Applied Science and Technology Research and Development Special [2015B020234002]
Oligosaccharides, important bioactive substances in traditional Chinese herbal medicine, have various biological activities such as anticancer, antioxidant, and anti-inflammatory effects. Structural analysis is crucial for studying their activities, but the complexity of carbohydrate compounds hinders research in this area.
Most of traditional Chinese herbal medicine (TCHM) substances come from medicinal plants, among which oligosaccharides have gradually attracted widespread attention at home and abroad due to their important biological activities and great medicinal potential. Numerous in vitro and in vivo experiments exhibited that oligosaccharides possess various activities, such as antitumor, anti-oxidation, modulate the gut microflora, anti-inflammatory, anti-infection, and immune-regulatory activities. Generally, biological activities are closely related to chemical structures, including molecular weight, monosaccharide composition, glycosidic bond connection, etc. The structural analysis of oligosaccharides is an important basis for studying their structure-activity relationship, but the structural diversity and complexity of carbohydrate compounds limit the study of oligosaccharides activities. Understanding the structures and biological functions of oligosaccharides is important for the development of new bioactive substances with natural oligosaccharides. This review provides a systematic introduction of the current knowledge of the chemical structures and biological activities of oligosaccharides. Most importantly, the reported chemical characteristics and biological activities of the famous TCHM oligosaccharides were briefly summarized, including Morinda officinalis, Rehmannia glutinosa, Arctium lappa, Polygala tenuifolia, Panax ginseng, Lycium barbarum and Astragalus membranaceus. TCHM oligosaccharides play an important role in nutrition, health care, disease diagnosis and prevention as well as have broad application prospects in the field of medicine.
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