期刊
BIO-PROTOCOL
卷 11, 期 8, 页码 -出版社
BIO-PROTOCOL
DOI: 10.21769/BioProtoc.3999
关键词
COVID-19; SARS-CoV-2; Phylogenetic analysis; Genomes; Coronavirus
类别
资金
- Council of Scientific and Industrial Research (CSIR India)
- GATE Fellowship from Council of Scientific and Industrial Research
COVID-19, originating as a local outbreak in Hubei province, China, has now become a global pandemic posing a major threat to healthcare systems worldwide. Efforts have been made to generate genome sequence data for the virus, enabling in-depth analysis and understanding of the disease, its origin, and its epidemiology. Systematic phylogenetic analysis is a powerful tool for tracking virus transmission patterns and identifying potential interventions.
COVID-19, the disease caused by the novel SARS-CoV-2 coronavirus, originated as an isolated outbreak in the Hubei province of China but soon created a global pandemic and is now a major threat to healthcare systems worldwide. Following the rapid human-to-human transmission of the infection, institutes around the world have made efforts to generate genome sequence data for the virus. With thousands of genome sequences for SARS-CoV-2 now available in the public domain, it is possible to analyze the sequences and gain a deeper understanding of the disease, its origin, and its epidemiology. Phylogenetic analysis is a potentially powerful tool for tracking the transmission pattern of the virus with a view to aiding identification of potential interventions. Toward this goal, we have created a comprehensive protocol for the analysis and phylogenetic clustering of SARS-CoV-2 genomes using Nextstrain, a powerful open-source tool for the real-time interactive visualization of genome sequencing data. Approaches to focus the phylogenetic clustering analysis on a particular region of interest are detailed in this protocol.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据