期刊
FOOD MICROBIOLOGY
卷 65, 期 -, 页码 64-73出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fm.2017.01.017
关键词
Staphylococcus aureus; Sub-Saharan Africa; Milk products; Food safety; One health; Dairy
资金
- World Food System Center of ETH Zurich, Switzerland
- Institute of Food Safety and Hygiene from the University of Zurich
- North-South Centre of ETH Zurich
- UBS Optimus Foundation in Cote d'Ivoire, Kenya
- UBS Optimus Foundation in Cote d'Ivoire, Somalia
Staphylococcus aureus frequently isolated from milk products in sub-Saharan Africa (SSA) is a major pathogen responsible for food intoxication, human and animal diseases. SSA hospital-derived strains are well studied but data on the population structure of foodborne S. aureus required to identify possible staphylococcal food poisoning sources is lacking. Therefore, the aim was to assess the population genetic structure, virulence and antibiotic resistance genes associated with milk-derived S. aureus isolates from Cote d'Ivoire, Kenya and Somalia through spa-typing, MLST, and DNA microarray analysis. Seventy milk S. aureus isolates from the three countries were assigned to 27 spa (7 new) and 23 (12 new) MLST sequence types. Milk-associated S. aureus of the three countries is genetically diverse comprising human and livestock-associated clonal complexes (CCs) predominated by the CC5 (n = 10) and COO (n = 9) isolates. Panton-Valentine leukocidin, toxic shock syndrome toxin and enterotoxin encoding genes were predominantly observed among human-associated CCs. Penicillin, fosfomycin and tetracycline, but not methicillin resistance genes were frequently detected. Our findings indicate that milk-associated S. aureus in SSA originates from human and animal sources alike highlighting the need for an overarching One Health approach to reduce S. aureus disease burdens through improving production processes, animal care and hygienic measures. (C) 2017 Elsevier Ltd. All rights reserved.
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