期刊
PUERTO RICO HEALTH SCIENCES JOURNAL
卷 40, 期 1, 页码 6-11出版社
UNIV PUERTO RICO MEDICAL SCIENCES CAMPUS
关键词
Radiotherapy-related fatigue; Intestinal injury; Dysbiosis
资金
- National Institute of Nursing Research (NINR) of the National Institutes of Health (NIH) [F32NR016618]
- University of Puerto Rico (UPR) NIH [2U54MD007587, CA096297/CA096300]
Radiotherapy-induced intestinal injury and gut microbial dysbiosis are believed to contribute to cancer-related fatigue. Limited but promising evidence suggests that interventions targeting gut mucosal barrier dysfunction and microbial perturbation may improve fatigue in cancer patients.
Radiotherapy treatment-induced intestinal injury and gut microbial perturbation/dysbiosis have been implicated in the pathobiology of cancer-related fatigue. The objective of this brief review was to explore the available evidence of the relationship between intestinal injury and self-reported fatigue, especially among cancer patients. The scientific evidence-including our own-linking gut mucosal barrier dysfunction and gut microbial perturbation/dysbiosis induced by cancer treatment with worsening of cancer-related fatigue (perhaps through the gut-brain axis) is limited but promising. Emerging data suggest that lifestyle interventions and the administration of specific probiotics may favorably modulate the gut microbiota and potentially mediate beneficial effects leading to improvements in fatigue.
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