期刊
STEM CELL REVIEWS AND REPORTS
卷 17, 期 5, 页码 1635-1646出版社
SPRINGER
DOI: 10.1007/s12015-021-10162-6
关键词
Dental pulp stem cells; Regenerative potential; Stem cells differentiation; Angiogenesis; Revascularization
资金
- Universita degli Studi dell'Aquila within the CRUI-CARE Agreement
The newly discovered dental pulp derived stem cells (DPSCs) have the potential to be tools for regenerative medicine, originating from the neural crest and involved in dentin homeostasis. They contribute to bone remodeling and differentiation into various tissues, and also influence angiogenesis by releasing secretory factors or differentiating into vascular and perivascular cells.
A new source of mesenchymal stem cells has recently been discovered, the so-called dental pulp derived stem cells (DPSCs) which therefore could represent potentially tools for regenerative medicine. DPSC originate from the neural crest and are physiologically involved in dentin homeostasis; moreover, they contribute to bone remodeling and differentiation into several tissues including cartilage, bone, adipose and nervous tissues. DPSCs have also been shown to influence the angiogenesis process, for example through the release of secretory factors or by differentiating into vascular and/or perivascular cells. Angiogenesis, that has a pivotal role in tissue regeneration and repair, is defined as the formation of new vessels from preexisting vessels and is mediated by mutual and reciprocal interactions between endothelial cells and perivascular cells. It is also known that co-cultures of perivascular and endothelial cells (ECs) can form a vascular network in vitro and also in vivo. Since DPSCs seem to have characteristics similar to pericytes, understanding the possible mechanism of interaction between DPSCs and ECs during neo-angiogenesis is dramatically important for the development of advanced clinical application in the field of regeneration.
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