3.8 Article

The pancreatic beta cell: an intricate relation between anatomical structure, the signalling mechanism of glucose-induced insulin secretion, the low antioxidative defence, the high vulnerability and sensitivity to diabetic stress

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

Bastian Kruemmel et al.

Summary: Pro-inflammatory cytokines play a crucial role in beta-cell destruction in type 1 diabetes mellitus, while the involvement of ferroptosis in the pathogenesis of the disease has not been clearly defined. The antioxidative enzyme GPx4 is predominantly expressed in beta-cells, and its overexpression as well as the ferroptosis inhibitor ferrostatin-1 can effectively attenuate beta-cell death. Nitric oxide produced during pro-inflammatory cytokine action prevents the induction of ferroptosis, favoring apoptosis as the primary cell death mechanism in beta-cells.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Article Chemistry, Multidisciplinary

Biological chemistry of superoxide radicals

Christine C. Winterbourn

CHEMTEXTS (2020)

Article Biochemistry & Molecular Biology

Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-βH1 beta-cells

T. Plotz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Biochemistry & Molecular Biology

Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells

Sigurd Lenzen

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

Review Biochemistry & Molecular Biology

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

Gerd P. Bienert et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

Review Biochemistry & Molecular Biology

A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status

Sigurd Lenzen

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells

Ilir Mehmeti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Endocrinology & Metabolism

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic beta-cells

W. Gehrmann et al.

DIABETES OBESITY & METABOLISM (2010)

Article Endocrinology & Metabolism

Peroxiredoxin III protects pancreatic β cells from apoptosis

Gabriele Wolf et al.

JOURNAL OF ENDOCRINOLOGY (2010)

Article Biochemistry & Molecular Biology

Oxidative stress:: the vulnerable β-cell

Sigurd Lenzen

BIOCHEMICAL SOCIETY TRANSACTIONS (2008)

Review Endocrinology & Metabolism

The mechanisms of alloxan- and streptozotocin-induced diabetes

S. Lenzen

DIABETOLOGIA (2008)