期刊
RSC ADVANCES
卷 11, 期 15, 页码 9021-9028出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra10000e
关键词
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资金
- National Natural Science Foundation of China [21904117]
- Zhejiang Provincial Natural Science Foundation of China [LY20B050007, LY21B050003]
- Science Foundation of Zhejiang Sci-Tech University [18062241-Y]
- Fundamental Research Funds of Zhejiang Sci-Tech University [2019Q060]
The study demonstrates the rapid and sensitive electrochemical detection of doxorubicin using electrochemically pretreated glassy carbon electrodes modified with vertically-ordered mesoporous silica films. The sensor showed ultra-high sensitivity, low limit of detection, wide linear range, and the ability for direct and reliable detection of doxorubicin in human whole blood without complex sample pretreatments, thanks to the excellent anti-fouling and anti-interference properties of the VMSF.
Direct and accurate detection of doxorubicin (DOX) in unprocessed human whole blood is of vital importance in medical diagnosis and monitoring. In this work, we demonstrate the utilization of electrochemically pretreated glassy carbon electrodes (p-GCE) modified with vertically-ordered mesoporous silica films (VMSF) for rapid and sensitive electrochemical detection of DOX. The electrochemically pretreated process is a simple, cost-effective and environmentally friendly approach for improving interface catalytic properties and introducing oxygen-containing groups into the GCE surface, which could be suitable for stably growing VMSF without any adhesive layer simultaneously retaining the underlying electrode activity. Benefiting from the highly sensitive electrode substrate of p-GCE and electrostatic preconcentration effect of VMSF, the present VMSF/p-GCE sensor was able to determine DOX with an ultrahigh sensitivity (23.94 mu A mu M-1) and a relatively low limit of detection (0.2 nM) and a rather wide linear range (0.5 nM to 23 mu M). Furthermore, direct and reliable electrochemical detection of DOX in human whole blood without complicated sample pretreatments was achieved owing to the excellent anti-fouling and anti-interference ability of VMSF.
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