期刊
EMERGING INFECTIOUS DISEASES
卷 27, 期 3, 页码 880-893出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2703.200852
关键词
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资金
- Fundacao para a Ciencia e Tecnologia (FCT) [PD/BD/113992/2015]
- FCT [PTDC/CVT-CVT/29510/2017]
- Microbiologia Molecular, Estrutural e Celular [LISBOA-01-0145-FEDER-007660, UID/Multi/04378/2019]
- COMPETE2020 Programa Operacional Competitividade e Internacionalizacao
- ONEIDA [LISBOA-01-0145-FEDER-016417]
- Fundos Europeus Estruturais e de Investimento from Programa Operacional Regional Lisboa2020
- FCT
- Fundação para a Ciência e a Tecnologia [PD/BD/113992/2015] Funding Source: FCT
Staphylococcus saprophyticus is a major cause of community-acquired UTIs in young women, with evidence suggesting the meat-production chain as a major source of the bacteria causing human UTIs. The pathogenic S. saprophyticus belongs to lineages with distinctive features that are globally and locally disseminated.
Staphylococcus saprophyticus is a primary cause of community-acquired urinary tract infections (UTIs) in young women. S. saprophyticus colonizes humans and animals but basic features of its molecular epidemiology are undetermined. We conducted a phylogenomic analysis of 321 S. saprophyticus isolates collected from human UTIs worldwide during 1997-2017 and 232 isolates from human UTIs and the pig-processing chain in a confined region during 2016-2017. We found epidemiologic and genomic evidence that the meat-production chain is a major source of S. saprophyticus causing human UTIs; human microbiota is another possible origin. Pathogenic S. saprophyticus belonged to 2 lineages with distinctive generic features that are globally and locally disseminated. Pangenome-wide approaches identified a strong association between pathogenicity and antimicrobial resistance, phages, platelet binding proteins, and an increased recombination rate. Our study provides insight into the origin, transmission, and population structure of pathogenic S. saprophyticus and identifies putative new virulence factors.
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