期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 39, 页码 4799-4802出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00709b
关键词
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资金
- National Nature Science Foundation of China [21871095]
- State Key Laboratory of Pulp and Paper Engineering [202012]
- Fundamental Research Funds for the Central Universities [x2hgD2200520]
A novel palladium-catalyzed cascade cyclization reaction has been developed for the construction of poly-heterocyclic scaffolds using alkenyl ethers and alkynyl oxime ethers. The strategy shows excellent regio- and chemoselectivities as well as good functional group tolerance, with the potential to further transform the products into diverse complex heterocycles.
A novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be further transformed to diverse complex heterocycles, demonstrating their potential applications in organic synthesis and medicinal chemistry.
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