期刊
AGING-US
卷 13, 期 6, 页码 8040-8054出版社
IMPACT JOURNALS LLC
关键词
Caenorhabditis elegans; autophagy; Lactobacillus fermentum; aging; HLH-30
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-9/2021-14/200042]
- A. Trifunovic's grant of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [SFB 1218, 269925409]
- Federation of European Microbiological Societies (FEMS) [FEMS-GO-2017-016]
This study demonstrates that heat-inactivated human commensal Lactobacillus can extend the lifespan of Caenorhabditis elegans and improve age-related physiological features by promoting HLH-30/TFEB-dependent autophagy to delay aging.
Gut homeostasis is maintained by the close interaction between commensal intestinal microbiota and the host, affecting the most complex physiological processes, such as aging. Some commensal bacteria with the potential to promote healthy aging arise as attractive candidates for the development of pro-longevity probiotics. Here, we showed that heat-inactivated human commensal Lactobacillus fermentum BGHV110 (BGHV110) extends the lifespan of Caenorhabditis elegans and improves age-related physiological features, including locomotor function and lipid metabolism. Mechanistically, we found that BGHV110 promotes HLH30/TFEB-dependent autophagy to delay aging, as longevity assurance was completely abolished in the mutant lacking HLH-30, a major autophagy regulator in C. elegans. Moreover, we observed that BGHV110 partially decreased the content of lipid droplets in an HLH-30-dependent manner and, at the same time, slightly increased mitochondrial activity. In summary, this study demonstrates that specific factors from commensal bacteria can be used to exploit HLH-30/TFEB-mediated autophagy in order to promote longevity and fitness of the host.
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