期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 19, 期 12, 页码 2603-2621出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob02052d
关键词
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资金
- NIH [GM065503, GM094755, GM129755]
- Robert A. Welch Foundation [Y-1362]
- NSF [CHE-0234811, CHE-0840509]
This review discusses various strategies for incorporating the signature pyrrole carboxamide moiety in the total syntheses of pyrrole-imidazole alkaloids (PIA). These alkaloids, derived from sponges, exhibit a wide range of biological activities, interesting skeletal diversity, and complexity.
In this review various strategies for the incorporation of the signature pyrrole carboxamide moiety in the total syntheses of pyrrole-imidazole alkaloids (PIA) are discussed. These so-called oroidin alkaloids have a broad range of biological activities and display interesting skeletal diversity and complexity. These alkaloids are sponge-derived secondary metabolites and thus far more than 200 members of the PIA family have been isolated over the past few decades. Methods range from classical amide bond forming processes to non-traditional bond formation including the de novo synthesis of the pyrrole itself.
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