期刊
ACS APPLIED NANO MATERIALS
卷 4, 期 2, 页码 2037-2051出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.0c03356
关键词
coacervate nanodroplets; controlled release; drug delivery; fluorescence enhancement; hydrophobic loading; pH-responsive; nanoassemblies
资金
- IIT Indore
- Council of Scientific & Industrial Research, India
This study demonstrates the efficient loading and sustained release of the hydrophobic drug Ru-Cur using carbon-dot and ATP-based coacervate nanodroplets fabricated with PDADMAC. The tailored structure and physicochemical properties of coacervate nanodroplets, along with high drug loading and negligible drug leakage, make them ideal nanocarriers for therapeutically active hydrophobic drugs. Experimental release profiles show diffusion- and swelling-controlled-release mechanism at pH values between 7.4 and 6, and diffusion- and erosion-controlled-release mechanism at lower pH, emphasizing the pH-responsive disassembly mechanism and potential theranostic applications of Ru-Cur-loaded coacervates.
Stimuli-responsive water-dispersible and structurally robust nanoassemblies find tremendous importance in the biomedical domain for delivery of therapeutically active hydrophobic drugs and bioimaging applications. Herein we have demonstrated the loading of a hydrophobic model anticancer drug, [(p-cymene)Ru(curcuminato)-CI] (Ru-Cur), inside hydrophobic compartments of different nanoassemblies, namely, micelles, liposomes, and coacervate nanodroplets, and studied the in vitro pH- and temperature-dependent controlled-release profiles. In the present study, both carbon-dot and adenosine triphosphate (ATP)-based coacervate nanodroplets have been fabricated in the presence of poly(diallyldimethylammonium chloride) (PDADMAC). It has been observed that the coacervate nanodroplets provide an ideal microenvironment for efficient loading (loading content = 31.2%, and encapsulation efficiency = 99.6%) and sustained release of the hydrophobic drug. The tailorability in the structure and physicochemical properties of coacervate nanodroplets along with high drug loading and negligible drug leakage at physiological conditions makes them ideal nanocarriers over other conventional nanoassemblies. Experimental release profiles for Ru-Cur-loaded ATP nanodroplets at different pH values fit well with a semiempirical power law model. The fitted parameters reveal diffusion- and swelling-controlled-release mechanism in the pH range between 7.4 and 6 and diffusion- and erosion-controlled-release mechanism at pH S. Moreover, it has been found that the temperature has a profound influence on the drug-release profiles. The present study provides fundamental insight into the pH-responsive disassembly mechanism and highlights the potential importance of these Ru-Cur-loaded coacervates toward various theranostic applications.
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