期刊
FOOD CHEMISTRY
卷 221, 期 -, 页码 1763-1769出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2016.10.107
关键词
Salting-out assisted liquid-liquid extraction; Ultra-high performance liquid chromatography tandem mass spectrometry; Infant foods; Tetracyclines; Antibiotics
资金
- Junta de Andalucia (Excellence Project) [P12-AGR-1647]
The use of salting-out assisted liquid-liquid extraction (SALLE) combined with ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) has been evaluated for the determination of tetracyclines in infant foods based on meat and vegetables or in milk. To obtain satisfactory extraction efficiencies for the studied analytes, several parameters affecting the SALLE procedure were optimized. Analytical performances of the method were satisfactory, obtaining limits of quantification lower than 0.48 mu g kg(-1) in all cases. The precision, expressed as relative standard deviation (%, RSD) was below 11.3%. The extraction efficiency for fortified samples ranged from 89.2 to 96.8%, with RSDs lower than 7.3%. Matrix effect was evaluated for all samples studied, being lower than |21|% in all cases. In relation to the low solvent consumption, the proposed methodology could be considered rapid, cheap and environmentally friendly. Its applicability has been successfully tested in a wide range of infant foods. (C) 2016 Elsevier Ltd. All rights reserved.
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