期刊
CEREBRAL CORTEX
卷 31, 期 3, 页码 1464-1477出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhaa287
关键词
episodic memory; healthy aging; multitrait-multimethod model; structural equation modeling
资金
- European Commission [732592]
- German Federal Ministry of Education and Research [01GQ1421B]
- MINERVA program of the Max Planck Society
The study examined the impact of structural integrity of hippocampal and cortical gray matter on episodic memory in older adults, revealing significant associations between the integrity of hippocampus and parahippocampus with episodic memory, especially in men. Multimodal factors of structural brain integrity may enhance our understanding of human memory aging.
Maintained structural integrity of hippocampal and cortical gray matter may explain why some older adults show rather preserved episodic memory. However, viable measurement models for estimating individual differences in gray matter structural integrity are lacking; instead, findings rely on fallible single indicators of integrity. Here, we introduce multitrait-multimethod methodology to capture individual differences in gray matter integrity, based on multimodal structural imaging in a large sample of 1522 healthy adults aged 60-88 years from the Berlin Aging Study II, including 333 participants who underwent magnetic resonance imaging. Structural integrity factors expressed the common variance of voxel-based morphometry, mean diffusivity, and magnetization transfer ratio for each of four regions of interest: hippocampus, parahippocampal gyrus, prefrontal cortex, and precuneus. Except for precuneus, the integrity factors correlated with episodic memory. Associations with hippocampal and parahippocampal integrity persisted after controlling for age, sex, and education. Our results support the proposition that episodic memory ability in old age benefits from maintained structural integrity of hippocampus and parahippocampal gyrus. Exploratory follow-up analyses on sex differences showed that this effect is restricted to men. Multimodal factors of structural brain integrity might help to improve our biological understanding of human memory aging.
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