期刊
JOURNAL OF CONTROLLED RELEASE
卷 329, 期 -, 页码 1172-1197出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2020.10.046
关键词
Electrospinning; Electrospraying; Protein encapsulation; Drug delivery; Tissue engineering
资金
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [824007]
- EPSRC [EP/L01646X/1]
- UA the MRC [MC_PC_17180]
- Marie Curie Actions (MSCA) [824007] Funding Source: Marie Curie Actions (MSCA)
- MRC [MC_PC_17180] Funding Source: UKRI
This review explores the potential of electrohydrodynamic (EHD) techniques in developing peptide and protein delivery systems, discussing the principles of various EHD methods and encapsulation of biological molecules using these approaches, as well as exploring the possibilities of localized delivery with stimuli-responsive systems and summarizing the advantages and challenges of electrospun and electrosprayed protein delivery systems.
Given the increasing interest in the use of peptide- and protein-based agents in therapeutic strategies, it is fundamental to develop delivery systems capable of preserving the biological activity of these molecules upon administration, and which can provide tuneable release profiles. Electrohydrodynamic (EHD) techniques, encompassing electrospinning and electrospraying, allow the generation of fibres and particles with high surface area-to-volume ratios, versatile architectures, and highly controllable release profiles. This review is focused on exploring the potential of different EHD methods (including blend, emulsion, and co /multi-axial electrospinning and electrospraying) for the development of peptide and protein delivery systems. An overview of the principles of each technique is first presented, followed by a survey of the literature on the encapsulation of enzymes, growth factors, antibodies, hormones, and vaccine antigens using EHD approaches. The possibility for localised delivery using stimuli-responsive systems is also explored. Finally, the advantages and challenges with each EHD method are summarised, and the necessary steps for clinical translation and scaled-up production of electrospun and electrosprayed protein delivery systems are discussed.
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